Natural around Chicago, Illinois to an Italian-American family, he made his acting debut in the 1969 stage production of Hair.

Mantegna married Arlene Vrhel (December 3, 1975-present). It keep around ii tykes.

He debuted in Broadway in Working (1978). He as well helped write Bleacher Bums, an award-winning play. He won the Tony award for his portrayal of Richard Roma within David Mamet's play Glengarry Glen Ross.

He processed his feature motion picture debut in Medusa Challenger (1977). He played womanizing tooth doctor Bruce Fleckstewithin in Compromising Positions (1985). More early motion picture include co-starring roles in The Money Pit (1986), Weeds (1987) and Suspect (1987). He besides starred in the critically acclaimed movies House of Games (1987) and Things Change (1988), for which he and co-star Don Ameche both received a Better Actor Award at the Venice Film Festival. Within 1991, Mantegna starred in the highly praised police force thriller Homicide. He as well has the revenant role in the alive series The Simpsons as mob boss Anthony "Fat Tony" D'Amico. He insists in voicing a character each instance he appears, disregarding how else little dialogue he has.

Joe Mantegna received a Lifetime Achievement Award in April 26, 2004, at the Los Angeles Italian Film Festival.

Selected filmography
Three Amigos 1986 Harry Flugleman The Godfather Part III (1990) ... Joey Zaza Homicide (1991) ... Detective Bobby Gold Bugsy (1991) ... George Raft ''Baby's Day Out (1994) ... Eddie a kidnapper More Dogs Than Bones (2000) De Salvo

Selected TV roles
The Rat Pack (1998) made-for-TV moving-picture show ... Dean Martin The Simpsons'' animated series ... voice Fat Tony, Springfield's mob boss Joan of Arcadia series ... May Girardi, Arcadia's captain & Joan's father